Fig 1.
Enrollment and result of plasma PCR.
The diagram represents the number of patients admitted to Yokohama Municipal Citizen’s Hospital, patients enrolled into the study, and the result of plasma PCR assay.
Table 1.
Association between plasma PCR status and other clinical data.
Fig 2.
Outcome of the patients in each group.
In the RNAemia group, 85.7% (twelve out of 14) were critical cases, including fatal cases, which accouted for 42.9% (six out of 14). In contrast, in the negative group, critical cases accouted for only 7.7% (six out of 78) and 3.8% (three out of 78) of the patients who died.
Fig 3.
Distribution of Ct value of the nasopharyngeal PCR in each group.
Each red rhombus represents critical cases including fatal cases, whereas each blue circle represents mild to severe cases. If nasopharyngeal PCR was negative, Ct value is represented as 40 in this figure. The median of Ct value of the nasopharyngeal PCR was significantly lower in RNAemia group than that in the negative group. While all the patients whose Ct value of nasopharyngeal PCR was <22 (represented as horizontal blue line) were critical in the RNAemia group, only three out of 16 those patients (18.8%) in negative group were critical.
Table 2.
Univariate logistic regression analysis of each factor associated with mortality and critical condition.
Table 3.
Mulivariate logistic regression analysis for the critical condition.