Fig 1.
A PRISMA flow diagram illustrates the search results, de-duplication, screening and the selection process.
Fig 2.
Network graphs of eligible comparisons for efficacy.
The size of the circles is proportional to sample size, and the width of lines is proportional to the number of trials. Interventions: acarbose (ACR), alfacalcidol (ALF), anastrozole (ANZ), clomiphene citrate (CC), exenatide (EXN), folic acid (FA), flutamide (FLT) pure follicle-stimulating hormone (FSH), human menopausal gonadotropins (HMG), inositol (INS), letrozole (LET), liraglutide (LIR), metformin (MET), medroxyprogesterone acetate (MPA), N-acetyl cysteine (NAC), orlistat (ORL), pioglitazone (PGZ), placebo (PLC), rosiglitazone (RGZ), sibutramine (SBT), simvastatin (SMV), and troglitazone (TGZ). Acarbose+clomiphene citrate (ACR+CC), alfacalcidiol+metformin (ALF+MET), atorvastatin+metformin (ATR+MET), bromocriptine+clomiphene citrate (BRM+CC), bromocriptine+metformin (BRM+MET), clomiphene citrate+dexamethasone (CC+DEX), clomiphene citrate+ketoconazole (CC+KTZ), clomiphene citrate+l-carnitine (CC+LC), clomiphene citrate+l-carnitine+metformin (CC+LC+MET), clomiphene citrate+metformin (CC+MET), clomiphene citrate+N-acetylcysteine (CC+NAC), clomiphene citrate+rosiglitazone (CC+RGZ), chlormadinone acetate+ethinylestradiol (CHA+EE), cyproterone acetate+ethinylestradiol (CPA+EE), cyproterone acetate+ethinylestradiol+metformin (CPA+EE+MET), cyproterone acetate+ethinylestradiol+metformin+orlistat (CPA+EE+MET+ORL), cyproterone acetate+ethinylestradiol+orlistat (CPA+EE+ORL), cyproterone acetate+ethinylestradiol+spironolactone (CPA+EE+SPR), dexamethasone+metformin (DEX+MET), desogestrel+ethinylestradiol (DGT+EE), drospirenone+ethinylestradiol (DPN+EE), drospirenone+ethinylestradiol+metformin (DPN+EE+MET), ethinylestradiol+flutamide+levonorgestrel (EE+FLT+LVT), ethinylestradiol+gestodene (EE+GTN), ethinylestradiol+metformin+norgestimate (EE+MET+NRG), ethinylestradiol+norgestimate (EE+NRG), folic acid+inositol (FA+INS), flutamide+metformin (FLT+MET), human menopausal gonadotropins+ leuprolide (HMG+LPR), inositol+monacolin k (INS+MNK), letrozole+metformin (LET+MET), metformin+rosuvastatin (MET+RSV), and metformin+simvastatin (MET+SMV).
Table 1.
Shows baseline and summary data of patients in included studies.
Fig 3.
Forest plots show the mean difference (MD) of different interventions compared with placebo for each outcome, along with the associated 95% CI.
Interventions: acarbose (ACR), alfacalcidol (ALF), anastrozole (ANZ), clomiphene citrate (CC), exenatide (EXN), folic acid (FA), flutamide (FLT) pure follicle-stimulating hormone (FSH), human menopausal gonadotropins (HMG), inositol (INS), letrozole (LET), liraglutide (LIR), metformin (MET), medroxyprogesterone acetate (MPA), N-acetyl cysteine (NAC), orlistat (ORL), pioglitazone (PGZ), placebo (PLC), rosiglitazone (RGZ), sibutramine (SBT), simvastatin (SMV), and troglitazone (TGZ). Acarbose+clomiphene citrate (ACR+CC), alfacalcidiol+metformin (ALF+MET), atorvastatin+metformin (ATR+MET), bromocriptine+clomiphene citrate (BRM+CC), bromocriptine+metformin (BRM+MET), clomiphene citrate+dexamethasone (CC+DEX), clomiphene citrate+ketoconazole (CC+KTZ), clomiphene citrate+l-carnitine (CC+LC), clomiphene citrate+l-carnitine+metformin (CC+LC+MET), clomiphene citrate+metformin (CC+MET), clomiphene citrate+N-acetylcysteine (CC+NAC), clomiphene citrate+rosiglitazone (CC+RGZ), chlormadinone acetate+ethinylestradiol (CHA+EE), cyproterone acetate+ethinylestradiol (CPA+EE), cyproterone acetate+ethinylestradiol+metformin (CPA+EE+MET), cyproterone acetate+ethinylestradiol+metformin+orlistat (CPA+EE+MET+ORL), cyproterone acetate+ethinylestradiol+orlistat (CPA+EE+ORL), cyproterone acetate+ethinylestradiol+spironolactone (CPA+EE+SPR), dexamethasone+metformin (DEX+MET), desogestrel+ethinylestradiol (DGT+EE), drospirenone+ethinylestradiol (DPN+EE), drospirenone+ethinylestradiol+metformin (DPN+EE+MET), ethinylestradiol+flutamide+levonorgestrel (EE+FLT+LVT), ethinylestradiol+gestodene (EE+GTN), ethinylestradiol+metformin+norgestimate (EE+MET+NRG), ethinylestradiol+norgestimate (EE+NRG), folic acid+inositol (FA+INS), flutamide+metformin (FLT+MET), human menopausal gonadotropins+ leuprolide (HMG+LPR), inositol+monacolin k (INS+MNK), letrozole+metformin (LET+MET), metformin+rosuvastatin (MET+RSV), and metformin+simvastatin (MET+SMV).
Fig 4.
A rankogram show the cumulative ranking of the average SUCRA values for each intervention across all metabolic and hormonal parameters.