Table 1.
Ventilator settings.
Fig 1.
BL = baseline; SLV = single lung ventilation; hCO = high cardiac output; PEEPt = PEEP trial; wLPA = wedged left main pulmonary artery; WLL = whole-lung lavage; MIGET: Multiple inert gas elimination technique.
The sequence of interventions was:
- animals #1,2,5: BL–SLV–hCO–wLPA
- animals #3, 4, 6: BL–hCO–SLV–wLPA
- animal #7, 9, 11: BL #1—SLV–wLPA–BL #2 –WLL-PEEPt
- animal #8, 10: BL #1—wLPA–SLV–BL #2 –WLL-PEEPt.
Fig 2.
MIGET = multiple inert gas elimination technique; PA = pulmonary artery.
Table 2.
Hemodynamic parameters.
Fig 3.
Results for respiratory enthalpy, dead space and venous admixture.
A, pooled results for animal 1–6; B, pooled results for animals 7–11; C, results for each individual animal of series 7–11. For A and B, data are given as mean ±SD, for C data points are single measurements.
Table 3.
Results for RE, PaO2/FiO2 ratio, dead space and venous admixture.
Fig 4.
V/Q distributions measured by MMIMS-MIGET.
A, Pooled V/Q distributions of all MMIMS-MIGET measurements and B, V/Q distributions of the first and second baseline conditions for animals 7–11. On the y-axis fractional perfusion (Q) and ventilation (V) with respect to cardiac output or minute ventilation are depicted. On the x-axis, the 50 V/Q compartments as measured by MMIMS-MIGET are displayed. Compartment “0” is intrapulmonary shunt. Fractional perfusion and ventilation are presented as blue lines and red dots, respectively.