Table 1.
Baseline characteristics of LonGenity and Einstein Aging Study cohorts.
Fig 1.
Frailty trajectories with 95% confidence intervals in LonGenity cohort.
Four trajectory classes identified: relatively stable (1), mild frail (2), moderate frail (3) and severely frail (4). The Y-axis depicts the frailty index scores (range 0 to 1) and x-axis follow-up time in years.
Fig 2.
Frailty trajectories with 95% confidence intervals in Einstein Aging Study cohort.
Four trajectory classes identified: relatively stable (1), mild frail (2), moderate frail (3) and severely frail (4). The Y-axis depicts the frailty index scores (range 0 to 1) and x-axis follow-up time in years.
Table 2.
LonGenity cohort baseline characteristics by frailty trajectory class.
P values for trend.
Table 3.
Frailty trajectories and mortality risk in LonGenity, Einstein Aging Study and pooled sample.
Fig 3.
Survival plots show the cumulative risk of mortality based on frailty trajectories in the pooled LonGenity and Einstein Aging sample.
Group 1 (relatively stable–reference group), 2 (mild frail), 3 (moderate frail) and 4 (severely frail).
Fig 4.
Association of proteins with frailty trajectories.
Volcano plot with top proteins associated with frailty trajectories after Bonferroni correction annotated and in red (see S3 Table in S1 File). X-axis denotes Beta estimate coefficients from linear model. Y-axis shows significance levels presented as -log10 (p-value).