Fig 1.
Flow chart of literature retrieval.
cfDNA, cell free DNA.
Table 1.
Characteristics of the included studies.
Fig 2.
Methodological quality graphs (risk of bias and applicability concerns), a) compared with the composite reference standard, b) compared with culture.
Fig 3.
Forest plot for the sensitivity and specificity of cell free DNA for the diagnosis of tuberculosis compared with a composite reference standard.
Fig 4.
Forest plot for the sensitivity and specificity of cell free DNA for the diagnosis of tuberculosis compared with culture.
Table 2.
Meta-regression analysis for different parameters compared with composite reference standard.
Fig 5.
Forest plot for the sensitivity and specificity of cell free DNA for the diagnosis of different types of tuberculosis compared with a composite reference standard.
a) pulmonary tuberculosis and extrapulmonary tuberculosis. b) different types of extrapulmonary tuberculosis. PTB, pulmonary tuberculosis; EPTB, extrapulmonary tuberculosis.
Table 3.
Subgroup analysis for different types of tuberculosis compared with a composite reference standard.