Table 1.
Description of the 13,552 TOPMed participants included in the main pooled whole genome sequence association analysis of MEAN handgrip strength and the 8,408 UK Biobank participants used for replication.
Table 2.
Main association results from the WGS association analysis of MEAN handgrip strength (P<2×10−8 in at least one analysis) in the pooled sample of 13,552 TOPMed participants, or stratified by study-reported population groups (AA), and by sex (AA men and AA women).
Table 3.
Significant and suggestive genes (P<10−5) associated with MEAN handgrip strength in TOPMed when aggregating rare variants with a minor allele count (MAC) greater or equal to 2 and a minor allele frequency (MAF) less than 1% using SKAT-O.