Table 1.
Participant demographics at baseline (M0).
Fig 1.
Repair-HD study participant disposition in this current study.
DAT Digitalized Arithmetic Task, HD Huntington Disease.
Fig 2.
A–Discriminant validity at baseline: significant differences between groups are represented by a star (p<0.05). B—Pearson correlations between arithmetic scores and cognitive measures (Bonferroni correction, p-values * 8) in HD patients. Blue colour indicates significant positive correlations and red colour significant negative correlation. White colour indicates non-significant correlation. C–Association between striatal volumes and accuracy, response time and IES in the arithmetic task (across the two operations) in HD patients. MDRS Mattis Dementia Rating Scale, SDMT symbol digit modalities test, HVLT Hopkins Verbal Memory Test, IR immediate recall, DR delayed recall.
Table 2.
Baseline and Month 1 comparisons on the DAT.
Fig 3.
A–Longitudinal Cohen’s f effect sizes for each cognitive test between month 1 and month 12 evaluations. B–Association between striatal change and response time and IES changes between Month 1 and Month 12 in HD patients. IES Inverse Efficiency Score, HVLT Hopkins Verbal Memory Test, DAT Digitalized Arithmetic Test, RT Response Time, IES Inverse Efficiency Score.
Table 3.
Results of model comparisons testing the main effect of time, interaction of time and group (Controls and HD patients) and post-hoc comparisons testing the M1-M12 change in performance in Controls and in HD patients.