Fig 1.
Study design scheme: (A). Vials containing ATCC bacteria at a concentration of 106 colony forming units (CFU/ml) were incubated in enriched medium and different antibiotic concentrations; (B). Turbidity measured by the HB&L system within the vial indicating the time of bacterial exponential growth.
Table 1.
Proportion and timing of cultures exhibiting exponential bacterial growth (EBG).
Fig 2.
Percent of positive cultures following exposure to different antibiotic concentrations.
*P (logrank) comparison between 1MIC and 103MIC.
Fig 3.
HB&L system readings over time in a single experiment set in which E. coli was exposed to increasing MICs of gentamicin, resulting in increased delay in exponential bacterial growth in 1MIC and 4MIC, while no growth was demonstrated at 103MIC.
Fig 4.
A patient with an infected knee following knee replacement was initially treated with intravenous vancomycin.
CITA treatment started on the day of surgery (day 2), and intravenous therapy was stopped on day 4. CITA treatment was stopped on the 24th day. Cultures demonstrated methicillin-resistant S. aureus and P. aeruginosa.