Table 1.
Patient characteristics.
Table 2.
Comparison of erythrocytes, reticulocytes, iron-related factors, and erythropoietin.
Fig 1.
CHr levels and iron status on Day 0.
ROC curves of (a) serum ferritin (b) TSAT and (c) s-Fe for CHr ≥ 32.0 pg on Day 0. The respective cutoff values for s-ft, TSAT, and s-Fe were ≥ 49.7 ng/mL (sensitivity 58.3%, specificity 61.1%, AUC 0.51), 21.6% (sensitivity 66.7%, specificity 94.4%, AUC 0.83, 95% CI 0.66–1.00), and 57.0 μg/dL (sensitivity 66.7%, specificity 94.4%, AUC 0.79, 95% CI 0.60–0.97). (d) Logistic model analysis with CHr ≥ 32.0 pg as the endpoint.
Fig 2.
CHr levels and iron status on Day 28.
ROC curves of (a) serum ferritin, (b) TSAT and (c) s-Fe for CHr ≥ 32.0 pg on Day 28. The respective cutoff values for s-ft and TSAT were ≥35.5 ng/mL (sensitivity 68.4%, specificity 81.8%, AUC 0.74, 95% CI 0.55–0.93), 16.2% (sensitivity 89.5%, specificity 81.8%, AUC 0.90, 95% CI 0.77–1.00) and 61.0 μg/dL (sensitivity 94.7%, specificity 72.7%, AUC 0.86, 95% CI 0.72–1.00). (d) Logistic model analysis with CHr ≥ 32.0 pg as the endpoint.
Fig 3.
CHr levels on Day 28 and iron status on Day 0.
ROC curves of (a) serum ferritin, (b) TSAT and (c) s-Fe on Day 0 for CHr ≥ 32.0 pg on Day 28. The respective cutoff values for s-ft, TSAT and s-Fe were at least at least 81.6 ng/mL (sensitivity 84.2%, specificity 63.6%, AUC 0.68, 95% CI 0.45–0.92), 23.9% (sensitivity 63.2%, specificity 81.8%, AUC 0.68, 95% CI 0.48–0.88) and 58.0 μg/dL (sensitivity 52.6%, specificity 90.9%, AUC 0.68, 95% CI 0.47–0.89), respectively. (d) Logistic model analysis with CHr ≥ 32.0 pg as the endpoint.
Fig 4.
Correlation between the change in CHr level and change in reticulocyte count from Day 0 to Day 28.
Change in CHr level showed a strong negative correlation with change in reticulocyte count in the low group (s-ft < 81.6 ng/mL) (p<0.001) but showed no correlation in the high group (s-ft ≥ 81.6 ng/mL) (p = 0.868). The slopes obtained by the linear regression analysis showed a significant difference between the two groups (p = 0.003).
Fig 5.
Correlation between change in Ret count from Day 0 to Day 28 and s-ft on Day 0.
Change in Ret count showed a strong positive correlation with s-ft on Day 0 (p = 0.014).