Fig 1.
Schematic presentation of IL-6/JAK/STAT3 pathway in pancreatic cancer cells and tumor microenvironment.
(PSC: pancreatic stellate cell, CAF: cancer associated fibroblast, TAM: tumor associated macrophages, MDSC: myeloid derived suppressor cells).
Fig 2.
PRISMA flow chart of included studies.
Table 1.
Bias assessment of preclinical studies.
Table 2.
Bias assessment of the clinical studies.
Table 3.
Characteristics of the included preclinical studies.
Table 4.
Characteristics of included clinical studies.
Table 5.
Summary of findings by drug.