Table 1.
Histopathological results of 481 lesions ≤ 6mm in diameter.
Table 2.
Dermatoscopic characteristics of 481 melanocytic lesions ≤ 6mm in diameter.
Table 3.
Comparison between clinical and dermatological hypotheses of cutaneous melanoma of 481 analyzed melanocytic lesions ≤ 6mm in diameter.
Table 4.
Validity of clinical and dermatoscopic criteria of 481 lesions ≤ 6mm in diameter.
Fig 1.
Case 1: Fig 1A: Clinically non-suspected lesion; Fig 1B: Suspected dermoscopy lesion with asymmetric structureless area; Fig 1C: H&E (Hematoxylin & Eosin 40X) Melanocytic lentiginous proliferation with small junctional nests. Some melanocytes adopt a supra-basal position. In the dermis, mononuclear inflammatory infiltrates include melanophages. Conclusion: 2mm diameter melanoma, Breslow 0.2mm. Case 2: Fig 1D: Clinically suspected lesion. Fig 1E: Suspected dermoscopy lesion with asymmetric globules; Fig 1F: H&E (40X) Melanocytes with hyperchromatic nucleus, enlarged, and moderately pleomorphic. They form nests of varied size where they are eventually horizontal. Intradermal nests consist of cells with mild pleomorphism adjacent to predominantly lymphocytic inflammatory infiltrates. Conclusion: 3mm diameter melanoma, Breslow 0.4mm. Case 3: Fig 1G: Clinically suspected lesion. Fig 1H: Suspected dermoscopy lesion with atypical asymmetrical pigmentary network. Fig 1I: Immunohistochemistry with Melan A (10X), showing the junctional melanocytic proliferation, the migration of melanocytes to the layers of the epidermis and the presence of Melan A positive cells in the dermis (loose), amid the mononuclear inflammatory infiltrate with melanophages. Conclusion: 5mm diameter melanoma, Breslow 0.2mm.
Fig 2.
Dermoscopic structures that helped with the diagnosis of some small size melanomas.
Fig 2A –Asymmetrical pigmentary network, asymmetric structureless area, blue-whitish veil. Fig 2B –Asymmetrical structureless area and streaks. Fig 2C –Asymmetrical structureless area, asymmetrical globules. Fig 2D –Asymmetrical pigmentary network and streaks. Fig 2E –Blue-whitish veil, asymmetric; asymmetrical pigmentary network. Fig 2F –Asymmetrical pigmentary network and asymmetrical structureless area.