Fig 1.
Flow diagram of the selection of studies.
Table 1.
Characteristics of included studies.
Table 2.
Outcome results.
Table 3.
Newcastle–Ottawa Scale for observational studies.
Fig 2.
Meta-analysis of the frequency of precocious puberty: Soy-based diet versus non-soy-based diet.
Table 4.
Summary of findings–quality of evidence according to GRADE approach of association between soy-based infant diet and the onset of puberty.
Fig 3.
Meta-analysis of mean age of menarche: Soy-based diet versus non-soy-based diet.
WMD: Unstandardized mean difference.
Fig 4.
Meta-analysis of height in the final follow-up: Soy-based diet versus non-soy-based diet.
WMD: Unstandardized mean difference. In the Duitama study height was measured at the beginning of puberty, and in the Strom study height was measured as an adult.