Table 1.
Demographic and anthropometric characteristics of the study groups.
Fig 1.
Percentile distribution of ALS and PD cohorts at enrollment based on z scores compared to age, sex and race matched United States Population (USP).
The ALS cohort had significantly lower total lean mass index (A) and appendicular lean mass index (B) compared to the PD cohort and USP. The PD cohort had significantly higher appendicular lean mass compared to USP (B). Total fat mass index (C) and percent fat (D) were not different between ALS and PD cohorts and USP. P-values are derived from Wilcoxon signed-rank test of ALS cohort vs USP, PD cohort vs USP, and from Wilcoxon rank-sum test of ALS cohort vs PD cohort.
Table 2.
Characteristics of ALS participants with 2 or more DEXA scans.
Table 3.
Multivariable mixed model analysis of change in body compositions and baseline body compositions, disease group and follow up duration.
Fig 2.
Baseline and change in DEXA measurements in ALS patients with two or more scans over the study period.
(A) ALSFRS-R, (B) Total Lean Mass Index, (C) Appendicular Lean Mass Index, (D) Total Fat Mass Index, and (E)) Percent Fat. Fast progressors are indicated with filled symbols and intermediate to slow progressors are indicated with open symbols. (F) Serial DEXA scans of patient A01 who was a fast progressor.
Fig 3.
Correlation between ΔALSFRS-R with baseline and longitudinal DEXA measurements.
ΔALSFRS-R correlates significantly with (A) ΔTotal Fat Mass Index, (B) ΔPercent Fat and (C) baseline percent fat. The correlation is not significant with (D) ΔBMI, (E) ΔTotal Lean Mass Index and (F) ΔAppendicular Lean Mass Index.