Fig 1.
Decision tree adapted for Argentina. ICU, intensive care unit; LRTI, lower respiratory tract infection; PCT, procalcitonin. Adapted from Mewes JC, Pulia MS, Mansour MK, Broyles MR, Nguyen HB, Steuten LM. The cost impact of PCT-guided antibiotic stewardship versus usual care for hospitalized patients with suspected sepsis or lower respiratory tract infections in the US: a health economic model analysis. PLOS One. 2019; 14(4):e0214222 [26].
Table 1.
Model parameters for sepsis and LRTI.
Epidemiological, resource use, effectiveness of PCT antibiotic stewardship and unit costs. Argentina, 2020.
Table 2.
Healthcare impact, cost categories, per patient and budget impact. Sepsis and LRTI patients. Standard of care, PCT strategy and differences. Year 1. Costs expressed in US dollars. Argentina, 2020.
Fig 2.
Impact of parameter variations on costs results per patient. Argentina, 2020. The figure shows how much the base case result (−$422.4 USD) would change if parameters were the maximum or minimum value instead of the base case. For example, the base case value for “Days on AB therapy_SoC (Sepsis)” was 10.0. If this parameter is changed to its minimum value of 7.0 (instead of 10.0) the model predicts a result of −$337 USD (grey bar). On the contrary, if it is changed to 21 (its maximum value) the model result would be −$736 USD. AB, antibiotic; ABx, antibiotics; LRTI, lower respiratory tract infection; PCT, procalcitonin; SoC, standard of care; USD, US dollars.
Fig 3.
Probability of saving costs for PCT strategy according to different scenarios. Argentina, 2020. AB, antibiotic; ICU, intensive care unit; LoS, length of stay; n, number; PCT, procalcitonin; SoC, standard of care.