Fig 1.
Paired comparisons of the automatically calculated ischemic core volumes (mL) for each patient measured using setting 1 (S1) versus settings 2 or 3 (S2/S3) using data from both hemispheres (A), for S1 versus S2/S3 using data from the affected hemisphere only (B); for S1 using data from the bilateral versus ipsilateral hemispheres (C), and for S2/S3 using data from the bilateral versus ipsilateral hemispheres (D).
Fig 2.
Bland Altman plot visualizing the relationship of the differences of measured volumes between those setting pairs with no significant differences detected using One Sample T tests.
A: Measured ischemic core differences between setting 1 (S1) versus setting 2 (S2) using data from both hemispheres. B: Measured penumbral differences using S1 versus S2 with data from both hemispheres. Upper and lower 95% confidence limits for the mean difference in volumes are visualized using thinnest dotted lines.
Table 1.
Comparison of ischemic core and penumbral volumes (in mL).
Fig 3.
Paired comparisons of the automatically calculated penumbral volumes (mL) for each patient for setting 1 (S1) versus setting 2 (S2), S1 versus setting 3 (S3), and S2 versus S3 using data from both hemispheres (A); S1 versus S2, S1 versus S3, and S2 versus S3 using data from the affected hemisphere only (B); and S1, S2, and S3 using data from the bilateral versus ipsilateral affected hemispheres (C).
Fig 4.
Illustrative computed tomographic perfusion map images for a patient with ischemic stroke.
(A–C) Data were postprocessed using the threshold values adapted to Syngo.via from another commercial software package (setting 1) (A), up-to-date company-recommended threshold values for Syngo.via (setting 2) (B), and older Syngo.via default parameters used in a reference study (setting 3) (C). (D) Limiting the analysis to the affected hemisphere using setting 3 yields a sensible, but faulty estimate of the penumbra and ischemic core volumes, potentially resulting in inaccurate diagnosis.
Table 2.
Associations between the ischemic core volume and final infarct volume in all patients and those patients with a successful recanalization (TICI 2b/3).