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Fig 1.

Study design.

COVID-19, coronavirus disease-2019; ICU, intensive care unit; NEWS2, National Early Warning Score 2; triple therapy, therapy with lopinavir/ritonavir and hydroxychloroquine.

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Table 1.

Characteristics of non-ICU patients treated with a triple therapy (lopinavir/ritonavir and hydroxychloroquine) compared to a control group.

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Table 1 Expand

Table 2.

Acute kidney injury and outcome in non-ICU patients.

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Table 2 Expand

Table 3.

Multivariable analysis for acute kidney injury adjusted for NEWS2.

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Table 3 Expand

Table 4.

Characteristics of ICU patients treated with a triple therapy (lopinavir/ritonavir and hydroxychloroquine) compared to a control group.

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Table 4 Expand

Table 5.

Acute kidney injury in ICU patients.

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Table 5 Expand

Fig 2.

Lopinavir/ritonavir and hydroxychloroquine (triple therapy) are associated with an increase in the incidence of Acute Kidney Injury (AKI).

Association between triple therapy and AKI (A) in non-intensive care unit (ICU) patients and (B) ICU patients. P-values refer to the total number of AKI; RRT, renal replacement therapy. (C) Association between triple therapy and the maximum serum creatinine value.

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Fig 2 Expand