Fig 1.
Main statins’ lipophilicity.
Lipophilicity is measured as C log P octanol/water, i.e. higher values correspond to higher lipophilicity. Note that simvastatin, lovastatin, and atorvastatin [29] are considered lipophilic statins, whereas rosuvastatin [30] is a highly hydrophilic statin.
Fig 2.
PRISMA flow chart.
Table 1.
Study characteristics.
Table 2.
Quantitative outcome measures.
Fig 3.
Forest plot for efficacy as mean value for depressive symptoms.
Fig 4.
Forest plot for acceptability (number of participants discontinuing treatment [dropouts] due to any cause) and for tolerability (number of participants discontinuing treatment [dropouts] due to adverse events).