Fig 1.
Flowchart of the derivation cohort.
SBT: Spontaneous Breathing Trial.
Table 1.
Patient characteristics—Derivation cohort.
Table 2.
Comparison of parameters between the extubation success and failure group in the derivation cohort.
Table 3.
Potential predictors of extubation failure based in an univariable logistic regression analysis (derivation cohort).
Fig 2.
ROC curves for RSBI in SBT (A), Dynamic Lung Compliance (B), Days of Mechanical Ventilation (C), Muscle Strength (D), Estimated GCS (E), Hematocrit (F), and Creatinine (G) used to distinguish the extubation success group from the failure group.
In the ROC curve analysis, the AUC was highest for RSBI in SBT (0.778), followed by the Dynamic Lung Compliance (0.700), Days of Mechanical Ventilation (0.686), Muscle Strength (0.662), Estimated GCS (0.630), Hematocrit (0.614), and Creatinine (0.587). ROC curve: receiver operating characteristic curve; RSBI in SBT: Rapid Shallow Breathing Index in Spontaneous Breathing Trial; Estimated GCS: Glasgow Coma Scale; AUC: area under the curve, CI: confidence interval.
Table 4.
Sensitivity and specificity at the cutoff of the highest Youden Index—Derivation cohort.
Fig 3.
Extubation Predictive Score—ExPreS.
Fig 4.
ROC curves for ExPreS from derivation cohort, used to distinguish the extubation success group from the failure group.
In the ROC curve analysis, the AUC was 0.875. ROC curve: receiver operating characteristic curve; ExPreS: Weaning and Extubation Predictive Index; AUC: area under the curve, CI: confidence interval.
Fig 5.
Extubation success probability of ExPreS.
The sensitivity, specificity and success rate (%) of ExPreS ≤ 44 points, ExPreS from 45 to 58 points, and ExPreS ≥ 59 points.
Fig 6.
Flowchart of the validation cohort.
SBT: Spontaneous Breathing Trial.
Fig 7.
ROC curves for ExPreS from validation cohort, used to distinguish the extubation success group from the failure group.
In the ROC curve analysis, the AUC was 0.971. ROC curve: receiver operating characteristic curve; ExPreS: Weaning and Extubation Predictive Index; AUC: area under the curve, CI: confidence interval.
Table 5.
Patient characteristics by cohort.