Fig 1.
A case from a high-risk patient with PDR at screening.
Image notes: (1) Top-left panel shows fundus photo and shows small dotted bleedings spots as well as curved
and dilated vessels
. (2) Bottom-left panel shows an optical coherence tomography (OCT) image of intraretinal cysts with swelling below the fovea and in the papillomacular bundle
. (3) Right panels are images from a fluorescein angiography and show regions of neovascularisation at the optic disc
and large areas of non-perfusion
present within the nasal and macula areas (i.e. an irregular foveal avascular zone). Images also show a small zone of sub-hyaloid bleeding.
Fig 2.
A case from a patient with moderate NPDR at screening.
Image notes: (1) Top-left panel shows a fundus photo and reveals a few small dotted bleedings spots . (2) Bottom-left panel shows an optical coherence tomography (OCT) image of intraretinal cysts with exudates
and mild edema
in the inferior temporal region. (3) Right panels show fluorescin angiography images from a normal optic disc, a mild intraretinal microvascular anomaly
and several microaneurysms
.
Fig 3.
Pictures showing the vitreous sampling procedure during a partial vitrectomy.
Image notes: (1) Top-left panel shows a picture of the surgeon performing a 2-port partial pars plana vitrectomy under control with the indirect ophthalmoscope. (2) Bottom-left panel shows the maneuver taking a vitreous probe. (3) Top-right panel shows an overview of the operative field. (4) Bottom-right panel shows the view through the indirect ophthalmoscope setup.
Fig 4.
Flow chart displaying non-randomized design of study.
Table 1.
Patient demographics and screening values.
Table 2.
Prior diabetic macular edema (DME) treatments at screening.
Fig 5.
The levels of growth and inflammatory factors (GIF) in patients with proliferative diabetic retinopathy (PDR) (top panel) and non-proliferative diabetic retinopathy (NPDR) (bottom panel).
Image notes: Individual data plotted using different shades of black (top panel) or blue (bottom panel) with the mean value shown as a solid horizontal line.