Table 1.
Summary of select model parameters (for a complete list of model parameters see S1 Table).
Fig 1.
Health outcomes for standard of care and point-of-care testing by (A) testing algorithm and (B) implementation model. ART: antiretroviral therapy; PoC: point-of-care testing; SoC: standard of care testing. Note: (A) testing algorithms are presented for the primary implementation model; (B) implementation models are presented for the PoC3 algorithm.
Fig 2.
Capital and recurrent costs for standard of care and point-of-care testing by (A) testing algorithm and (B) implementation model. PoC: point-of-care testing; SoC: standard of care testing. Note: (A) testing algorithms are presented for the primary implementation model; (B) implementation models are presented for the PoC3 algorithm.
Fig 3.
Incremental cost-effectiveness ratios for point-of-care testing by (A) algorithm and (B) implementation model. ART: antiretroviral therapy; ICER: incremental cost-effectiveness ratio; PoC: point-of-care testing; SoC: standard of care testing. Note: (A) testing algorithms are presented for the primary implementation model; (B) implementation models are presented for the PoC3 algorithm.
Fig 4.
Incremental cost-effectiveness ratios for sensitivity analyses of (A) intrinsic and (B) external factors affecting point-of-care testing. ART: antiretroviral therapy; ICER: incremental cost-effectiveness ratio; PoC: point-of-care testing; SoC: standard of care testing. Note: All sensitivity analyses were performed with the PoC3 algorithm and primary implementation model. For (A) and (B), PoC3 represents the results from the primary analysis with the baseline model parameters. For (A) PoC short lifespan refers to the time period covered by the manufacturer’s warranty; integrated use refers to use of the PoC machines across programs (HIV viral load and tuberculosis testing); long and short run time per test refers to the amount of staff time spent for sample collection (including pre-test counseling) and running the test. For (B) improved SoC refers to the proportion of children initiating ART within 60 days after SoC (ICER shown for PoC3 algorithm for the primary implementation model compared to SoC); retention rate refers to the proportion of children returning for subsequent testing at a later age. See S1 Table for the list of parameter values.
Fig 5.
Incremental cost-effectiveness ratios for multivariate sensitivity analysis showing best and worst cases by PMTCT coverage.
ART: antiretroviral therapy; ICER: incremental cost-effectiveness ratio; PMTCT: prevention of mother-to-child transmission. Note: All sensitivity analyses were performed with the PoC3 algorithm and primary implementation model. See S1 and S7 Tables for the list of parameter values for the primary analysis, best case, and worst case scenarios.