Table 1.
Structure and log P values of the proposed penetrants.
Fig 1.
log K of CAFF, MP and BP as a function of acetonitrile concentration using C4 column.
Fig 2.
log K of CAFF, MP and BP as a function of acetonitrile concentration using C18 column.
Fig 3.
log k of CAFF, MP and BP as a function of acetonitrile concentration using CN column.
Fig 4.
Elution of the analytes mixture at different injection volumes (25, 50 and 100μL) using A) C18 and B) CN columns.
Fig 5.
Comparison between the chromatogram for the mixture of analytes (continuous line) and that of the matrix (dotted line).
The concentration of the mixture is 25 μg/mL with respect to each analyte.
Table 2.
Linearity ranges, equations, r2 values and number of concentrations of the calibration curves for CAFF, MP and BP.
Table 3.
Data of accuracy and precision for CAFF, MP and BP.
Table 4.
Data of LOQ and LOD (μg/mL) for CAFF, MP and BP (n = 3).
Fig 6.
Diffusion profiles, through stratum corneum, of CAFF, MP and BP from their corresponding individual and ternary mixture emulgels.
The plot in the insert shows the points obtained at the early stage of the experiment. n = 4–6.