Table 1.
Detailed MRI acquisition parameters.
Table 2.
Detailed demographic and clinical data of patients with Multiple Sclerosis (MS).
Fig 1.
A 32 year-old woman with relapsing-remitting multiple sclerosis.
3D-Fast Gray Matter Acquisition with Phase Sensitive Inversion Recovery (3D-FGAPSIR) real-corrected (a) and second magnitude (b) images reformatted in the sagittal plane, providing more accurate detection and delineation of one anterior and one posterior C3 lesions (white arrow) and showing one supplementary distinct anterior C3 lesion (arrowhead) as compared to 3D-Short-Tau Inversion Recovery reformatted in the sagittal plane (c) and sagittal T2-weighted imaging (d). 3D-FGAPSIR also showing a posterior C2 lesion (black arrow) with a high reader-reported confidence, high delineation and high conspicuity, whereas the same lesion is hardly visible on the conventional dataset. 3D-FGAPSIR real-corrected image reformatted in the axial plane (e) localizing and delineating more precisely the C3 lesions as compared to 3D-STIR reformatted in the axial plane (f).
Fig 2.
A 23 year-old man with relapsing-remitting multiple sclerosis.
3D-Fast Gray Matter Acquisition with Phase Sensitive Inversion Recovery (3D-FGAPSIR) real-corrected (a) and second magnitude (b) images reformatted in the sagittal plane showing a single left posterior cervical spinal cord lesion (arrow), whereas no lesion was detected on both 3D-Short-Tau Inversion Recovery (STIR) reformatted in the sagittal plane (c) or sagittal T2-weighted imaging (d). 3D-FGAPSIR real-corrected image reformatted in the axial plane (e) confirming and precisely localizing the lesion, whereas no lesion was detected on 3D-STIR reformatted in the axial plane (f).
Fig 3.
Comparison of the number and distribution of multiple sclerosis lesions detected in the spinal cord with the conventional imaging dataset (grey) and the 3D-Fast Gray Matter Acquisition with Phase Sensitive Inversion Recovery (3D-FGAPSIR) dataset (black).
The Y-axis represents the number of lesions detected. The X-axis represents the spinal cords levels. The dot below T7 shows the median lower spinal cord level covered by the 3D-FGAPSIR. The horizontal line represents the full range of lower spinal cord levels covered by the 3D-FGAPSIR, with the minimal and maximal lower spinal cord levels represented by the two vertical dotted lines in T5 and T10.
Fig 4.
A 32 year-old man with relapsing-remitting multiple sclerosis.
3D-Fast Gray Matter Acquisition with Phase Sensitive Inversion Recovery (3D-FGAPSIR) first magnitude imaging reformatted in the sagittal plane (a) and sagittal T1-weighted imaging (b), showing a single cervical spinal cord enhanced lesion (arrow) corresponding to a clinically active lesion.