Table 1.
Treatment schedule.
Fig 1.
Effect of celecoxib (CXB 5 and 10 mg/kg) and atorvastatin (ATO 25 mg/kg) on the total body weight of rats.
The symbol ** and *** represent significant differences (P < 0.01 or P < 0.001 respectively) between treatment groups and heated oil only group (all were compared using two-way ANOVA followed by Tukey’s post hoc test).
Fig 2.
Effect of celecoxib (CXB 5 and 10 mg/kg) and atorvastatin (ATO 25 mg/kg) on the weight of (a) liver, (b) heart (c) kidney (d) lungs and (e) spleen in heated-oil induced hyperlipidaemia model in Sprague-Dawley rats.
Values are expressed as mean ± SEM (n = 6). The symbol * represents significant differences between treatment groups and heated oil only group (P < 0.05) (all were compared using one-way ANOVA followed by Newman-Keuls’ post hoc test).
Fig 3.
Effect of celecoxib (CXB 5 and 10 mg/kg), atorvastatin (ATO 25 mg/kg) on haematological parameters such as (a) white blood cells (b) red blood cells (RBCs) (c) haemoglobin (d) haematocrit (e) mean cell volume (MCV) (f) mean cell haemoglobin (g) mean cell haemoglobin concentration (MCHC) and (h) platelet in overheated-oil induced hyperlipidaemia in Sprague-Dawley rats.
Values are expressed as mean ± SEM (n = 6). There were no significant differences between treatment groups and the various controls.
Fig 4.
Effect of celecoxib (CXB 5 and 10 mg/kg), atorvastatin (ATO 25 mg/kg) on serum lipid parameters such as (a) AST (b) ALT (c) ALP and (d) urea; and (e) fasting blood sugar in overheated-oil induced hyperlipidaemia in Sprague-Dawley rats.
Values are expressed as mean ± SEM (n = 6). The symbols * and ** represents significant differences (P < 0.05 and P < 0.01 respectively) between treatment groups and heated oil only group (all were compared using one-way ANOVA followed by Newman-Keuls’ post hoc test).
Fig 5.
Effect of celecoxib (CXB 5 and 10 mg/kg), atorvastatin (ATO 25 mg/kg) on serum lipid parameters such as (a) cholesterol (b) triglycrides (c) low density lipoprotein (d) very low density lipoprotein and (e) high density lipoprotein cholesterol in overheated-oil induced hyperlipidaemia in Sprague-Dawley rats.
Values are expressed as mean ± SEM (n = 6). The symbols * and ** represents significant differences (P < 0.05 and P < 0.01 respectively) between treatment groups and heated oil only group (all were compared using one-way ANOVA followed by Newman-Keuls’ post hoc test).
Fig 6.
Effect of celecoxib (CXB 5 and 10 mg/kg) and atorvastatin (ATO 25 mg/kg) on the levels of serum cytokines such as (a) TNF-α and (b) IL-6 in overheated-oil induced hyperlipidaemia in Sprague-Dawley rats.
Values are expressed as mean ± SEM (n = 6). There were no significant differences between heated oil and other treatment groups (all were compared using one-way ANOVA followed by Newman-Keuls’ post hoc test).
Fig 7.
Representative photomicrographs of the liver of experimental animals showing the general histomorphology.
(A) naïve control group (B) unheated oil treated group (C) heated oil only treated group as negative control, (D) heated oil in addition to atorvastatin 25 mg/kg (E) heated oil in addition to celecoxib 5 mg/kg and (F) heated oil in addition to celecoxib 10 mg/kg. Scale bar is 50μ.