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Table 1.

PICOS selection criteria.

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Fig 1.

PRISMA diagram.

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Table 2.

Global Exon 20ins rates.

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Table 3.

Summary of prognostic impact of Exon20 insertions compared to other genotypes.

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Table 3 Expand

Table 4.

Overview of studies reporting the clinical burden of Exon20 insertions by line of therapy and drug class.

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Table 4 Expand