Fig 1.
Example Images and distribution of amyloid SUVR.
A: Example of a participant with amyloid SUVR = 3.2, age = 86, MMSE = 29 and ApoE = ε3/ε3. The 4mm Gaussian filtered image displays SUVR is scaled from 0–4.5 SUVR. B: example of a participant with amyloid SUVR = 1.2, age = 86, MMSE = 29 and ApoE = ε3/ε3. The SUVR image is scaled from 0–3.5 SUVR. C: histogram of cortical amyloid SUVR (reference region was bilateral cerebellar grey matter).
Table 1.
Overview on study sample.
Table 2.
Neuropsychological assessment results.
Table 3.
Results of WHOQOL-OLD split by amyloid load and with reference values.
Fig 2.
Plot of estimated marginal means of extraversion and neuroticism score against amyloid load.
Plot of the estimated marginal means of the two NeoFFI measures as estimated in the repeated measures model with the covariates age, sex and education. Neuroticism against amyloid quartiles is plotted in blue and extraversion in red. Variables were Box-Cox transformed.
Table 4.
Results of the cognitive and physical activity questionnaire.
Fig 3.
Correlation physical activity score against amyloid SUVR.
Scatter plot between physical activity score and amyloid SUVR. The correlation is significant (rho = -0.307, p = 0.032) and indicates that participants with higher physical activity have lower amyloid SUVR.
Fig 4.
Correlation between midlife extracurricular experiences and executive cognitive functions.
Significant correlation between executive function scores and midlife extracurricular experiences (measured with LEQ). Spearman’s rho = 0.513, p<0.001 or Pearson’s partial correlation (with covariates age, sex and education and Box-Cox corrected variables) r = 0.499, p = 0.001. Color indicates amyloid load quartiles (Quartile 1 lowest and Quartile 4 highest amyloid SUVR).
Fig 5.
Correlation matrix between lifetime-experiences and executive cognitive functions.
Correlation matrix between executive functions scores and Lifetime experience questionnaire scores. Color and numbers indicate the Spearman’s rho value. Color white indicates non-significance (p>0.05). Stars indicating significance level in the Spearman’s correlation and circles significance in the partial correlation with corrected variables (* or ° indicates significance on p = 0.05 level and ** or °° indicates significance on p = 0.01 level).