Fig 1.
A and B) Heatmaps representing the hierarchical clustering of AML cases according to the expression of the 911 probes associated with FLT3 ITD and TKD mutation status. The color coding of the bar indicates if a patient harbos a FLT3-ITD mutation (red bars), a FLT3-TKD mutation (green bars), both mutations (yellow bars) or no FLT3 mutation (light blue bars). C-E) Heatmaps representing the hierarchical clustering of AML cases according to the expression of the 911 probes associated with FLT3-ITD mutation status. No information about FLT3-TKD mutations was reported for patients in these databases. Red bars indicate FLT3-ITD cases and light blue bars indicate lack of FLT3-ITD mutation.
Fig 2.
Heatmaps representing the hierarchical clustering of AML cases according to the expression of the 595 matching genes in the RNAseq cohort (GSE146173).
The color coding of the bar follows the same pattern as that of Fig 1.
Table 1.
Differential distribution of recurrently mutated genes in wild-type FLT3 AML patients according to the presence or absence of the FLT3-like pattern (GSE146173).