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Fig 1.

PRISMA flow diagram describing the literature search and article selection process.

a Detailed reasons for exclusion are provided in S3 Table.

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Table 1.

Lactic acid-containing product details.

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Table 2.

Key findings of included studies.

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Fig 2.

Risk of bias assessment.

+ indicates a low risk of bias, -/+ indicates moderate risk of bias,—indicates high risk of bias,? indicates unknown risk, NA indicates bias is not applicable to the study. a Other sources of bias include whether confounders were appropriately accounted for and whether lactic acid-containing product details were sufficiently described in the manuscript. b One study disclosed receipt of funding from the lactic acid-containing product manufacturer. c Single arm prospective cohort study.

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