Fig 1.
Diagram of enrollment, follow-up, and analysis.
Fig 2.
Number of tested patients and observed test-positives per age group (n = 1460).
Fig 3.
Symptoms in the first three weeks after symptom onset for patients presenting early (≤ 7 days after symptom onset) or late (> 7 days after symptom onset).
Symptoms typically persisted longer in late presenters compared to early presenters. This was observed strongest for hyposmia/hypogeusia (p<0.001, FDR<0.05, indicated by ***), cough and rhinitis (p<0.05, FDR<0.3, indicated by *).
Fig 4.
Time-course of symptoms observed for early presenters patients (≤ 7 days from symptom onset to testing) (n = 65).
Observations are arranged by frequency. Dashed lines indicate the start of the second and third week after symptom onset. Bars in lighter color represent observations, where only a single patient developed a specific symptom. Grey trend lines are trends calculated as loess-smoother.
Fig 5.
Time-course of symptoms observed for late presenters (> 7 days from symptom onset to testing) (n = 22).
Observations are arranged by frequency. Dashed lines indicate the start of the second and third week after symptom onset. Bars in lighter color represent observations, where only a single patient developed a specific symptom. Grey trend lines are trends calculated as loess-smoother.
Table 1.
Symptoms reported by outpatients diagnosed with coronavirus disease 2019 (Covid-19).
Fig 6.
Positive and negative correlation of symptoms observed in individual patients.
Shown are all pairwise correlations, significant correlations are indicated by a background color (FDR≤0.05). Color codes in the color bar represent the size of the correlation coefficient r. Anti-correlation of symptoms (r≤0) is emphasized with diagonal stripes.