Fig 1.
The data analysis procedures of this study.
Blue words indicate input data. Brown words indicate the results of each step.
Fig 2.
SLiM compositions and phylogenetic analysis of orf1ab-encoding proteins and capsid proteins of coronaviruses.
(A) A total of 1,365 SLiMs were identified in 15 viral proteins encoded by orf1ab (nsp1-nsp10 and nsp12-nsp16). (B) A total of 114 SLiMs were identified in capsid proteins. Complete lists of SLiMs in (A) and (B) are shown in S2 Table. (C) Phylogenetic tree of representative orf1ab-encoding proteins. (D) Phylogenetic tree of representative capsid proteins. The number of tree branches that occurred in 1,000 bootstrap replicates are indicated at the branch point.
Table 1.
Number of SLiMs identified in coronavirus proteins.
Fig 3.
Venn diagram of number of human proteins interacting with coronavirus proteins mediated by SLiMs.
(A) common and different SLiM interacting proteins between different human coronavirus groups. (B) common and different SLiM interacting proteins among SARS-CoV, SARS-CoV-2 and MERS-CoV.
Table 2.
Thirty-five human proteins interact with SLiMs identified in SARS-CoV, SARS-CoV-2 and MERS-CoV proteins.
Table 3.
Twenty-two human proteins interact with SLiMs identified in SARS-CoV, SARS-CoV-2 or MERS-CoV proteins.
Fig 4.
Venn diagram of the number of target human pathway coronavirus proteins mediated by SLiMs.
(A) Common and different SLiM target pathways between different viral groups. (B) Common and different SLiM target pathways among SARS-CoV, SARS-CoV-2 and MERS-CoV.
Table 4.
Pathways associated with viral SLiM interacting proteins.
Fig 5.
Categories (based on the KEGG pathway database) and numbers of pathways that may be affected by coronavirus proteins.
Two hundred and nine pathways contain proteins that interact with 1,479 SLiMs identified in 16 coronavirus proteins (nsp1-nsp10, nsp12-nsp16 and capsid proteins).