Table 1.
Brief description of the seven studies.
Table 2.
Specification of prior distributions for model parameters.
Fig 1.
Example of posterior probability distribution of ER50 (A) and calculation of both censoring criteria (B-C).
Fig 2.
Example of a dose-response curve (A), posterior predictive check (B), prior and posterior distributions of parameters (C) and correlations between parameters (D).
Fig 3.
Censored ER50 according to both criteria and the seven decision thresholds for the shoot dry weight endpoint of the VV test from case study 1—species ALLCE.
The two orange triangles stand for the lowest and the highest tested rates. Vertical segments of three different colours (black, blue, red) represent the CI95 of ER50, the censored ER50 according to C1 and the censored ER50 according to C2, respectively; solid vertical segments are for bounded intervals while dotted vertical segments stand for right-unbounded intervals; the black horizontal line represents the median of the ER50 estimate.
Fig 4.
Example of three SSD analyses based respectively on ER50 medians, CI95 of ER50 and censored ER50 according to C1T0.5 for the shoot dry weight endpoint of the VV test from case study 1.
Blue points represent fractions of affected species (EPPO code) ordered by the median of their ER50. Solid blue horizontal segments stand for interval-censored ER50 by their CI95 and dotted ones stand for right-censored ER50. Solid red curves represent fitted SSD curves and dotted ones represent 95% confidence interval (CoI95) of the fitted SSD curves. Meaning of legends: Nb. ER50 (RC) stands for the number of ER50 (the number of right-censored ER50); Nb. distinct ER50 (RC) stands for the number of distinct ER50 (the number of distinct right-censored ER50); HR5[CoI95] stands for the estimated HR5 with its CoI95.
Table 3.
Comparison of results on HR5 based on different handling criteria for input ER50 values.