Table 1.
Agreement among phenotypic and genotypic DST assays.
Fig 1.
Distributions of drug resistance-conferring mutations with corresponding MIC values.
Each stacked column represents a collection of isolates colored by different genetic background. The dashed lines indicate the critical concentrations used for MYCOTB. The H37Rv control strain was susceptible to all anti-tuberculosis drugs and represents the wild-type.
Fig 2.
Comparisons between resistance-conferring mutations and MIC values of anti-TB drugs.
Only those anti-TB drugs are shown for which common mutations are associated with significant differences in MIC levels. The dashed lines indicate the critical concentrations used for MYCOTB. The size of each circle is proportional to the number of isolates. The color of circles indicate the MIC level from low (blue-green) to high (red).
Fig 3.
Comparison between heteroresistance (inferred from read frequencies of relevant SNPs) and MIC levels of Mtb.
Comparisons between heteroresistance (inferred from read frequencies of relevant SNPs) and MIC levels for each anti-TB drug. The dashed line indicates the critical concentrations used for MYCOTB. Only anti-TB drugs against which heteroresistance was inferred based on read frequencies are shown. The size of each circle is proportional to the number of isolates.