Table 1.
Clinical characteristics of the study population.
Fig 1.
Plasma levels of anti-elastase in TB-IRIS patients and controls.
Graphs show a comparison between groups (A), as well as changes over time for individual patients (B) in the median plasma levels of anti-elastase (U/ml) measured prior to ART, and at 3 months and 9 months of ART. Significant overall differences between TB-IRIS patients (red circles), HIV+TB+ (blue triangles), HIV+TB- (green squares), and HIV-TB- (yellow hexagons) controls were calculated using Kruskal-Wallis tests, with Dunn’s post-hoc test shown as capped lines to highlight specific differences between individual groups (A). Significant variation over time was calculated for each group using Friedman tests, with Dunn’s post-hoc test shown as capped lines to highlight specific differences between individual time points (B). Out of 17 TB-IRIS patients with samples available pre-ART, only 11 had samples available at both month 3 and month 9. The total number of patients analysed over time was thus 11 for each group. Analysis were performed between all groups at each time point, and between every time points for each group with the level of significance was set to P < 0.05. Non-significant p-values have been omitted from the graphs. Overall Kruskal-Wallis p-value was ap = 0.009 and overall Friedman p-value was bp ≤ 0.001.
Fig 2.
Plasma levels of other ANCAs in TB-IRIS patients and controls.
Graphs show a comparison between TB-IRIS patients (red circles), HIV+TB+ (blue triangles), HIV+TB- (green squares), and HIV-TB- (yellow hexagons) in the median plasma levels of anti- PR3 (A), -MPO (B), -BPI (C), -cathepsin (D), -lysozyme (E), and -lactoferin (F) (U/ml) measured prior to ART, and at 3 months and 9 months of ART. Analysis were performed between all groups at each time point using Kruskal-Wallis tests, with Dunn’s post-hoc test, and the level of significance set to P < 0.05. Non-significant p-values have been omitted from the graphs, as no significant values were observed.
Fig 3.
Plasma levels of other ANCAs over time in TB-IRIS patients and controls.
Graphs show changes over time for individual patients in the median plasma levels of anti- PR3 (A), -MPO (B), -BPI (C), -cathepsin (D), -lysozyme (E), and -lactoferrin (F) (U/ml) measured prior to ART, and at 3 months and 9 months of ART. Significant variation over time in TB-IRIS patients (red circles), HIV+TB+ (blue triangles), and HIV+TB- (green squares) controls was calculated for each group using Friedman tests, with Dunn’s post-hoc test shown as capped lines to highlight specific differences between individual time points. Out of 17 TB-IRIS patients with samples available pre-ART, only 11 had samples available at both month 3 and month 9. The total number of patients analysed over time was thus 11 for each group. No variation over time was calculated for HIV-TB- controls, since only 1 time point was available. Analysis were performed between all groups at each time point, and between every time points for each group with the level of significance was set to P < 0.05. Overall Friedman p-values were ap = 0.027, bp = 0.002, cp = 0.011, dp = 0.002, ep = 0.019.
Table 2.
Change in ANCA-levels at baseline vs 9 months in absolute (delta-)values.