Fig 1.
The integrated drug resistant TB diagnostic algorithm as per the Programmatic Management of Drug Resistant TB Guidelines, Revised National TB Programme, India, 2017.
aExtra-pulmonary TB bRifampicin resistant TB cRifampicin sensitive TB dFluoroquinolone eSecond-line injectables fFirst-line Line Probe Assay gSecond-line Line Probe Assay hIsoniazid iAll diagnosed TB patients (clinically diagnosed or microbiologically confirmed) were offered Xpert® MTB/Rif assay to know the rifampicin sensitivity status as per the Universal Drug Susceptibility policy since April 2018 in Karnataka state, India.
Table 1.
Operational definitions of the outcome variables used to assess the reach, completion, dates of collection, receipt and reporting of results for various diagnostic tests used for diagnosis of DR-TB in the integrated DR-TB diagnostic algorithm.
Table 2.
Demographic and clinical profile of TB patients diagnosed by Xpert® MTB/Rif assay between 1st July and 31st August 2018 at t13 selected Xpert laboratories in Karnataka, India.
Fig 2.
Cascade of integrated DR-TB diagnostic algorithm for Rifampicin sensitive TB patients (RS-TB) diagnosed at the 13 selected Xpert laboratories between 1st July and 31st August 2018 in Karnataka, India.
a First line–Line Probe Assay b Isoniazid c Rifampicin d Two were H resistant and one was H sensitive e Second line–Line Probe Assay f Fluoroquinolone g Second line injectable.
Fig 3.
Cascade of integrated DR-TB diagnostic algorithm for Rifampicin resistant TB (RR-TB) patients diagnosed at the 13 Xpert laboratories between 1st July and 31st August 2018 in Karnataka, India.
a Second line–Line Probe Assay b Fluoroquinolone c Second line injectable.
Table 3.
Timing of specimen collection, receipt and reporting of results of TB patients diagnosed between 1st July and 31st August 2018 at the 13 selected Xpert laboratories and their two linked reference laboratories in Karnataka, India.
Table 4.
Factors associated with samples not reaching the linked reference laboratories from patients diagnosed with TB at the 13 selected Xpert laboratories between 1st July and 31st August 2018 in Karnataka, India.
Table 5.
Factors associated with non-completion of the DR-TB diagnostic algorithm among the samples reaching the two linked reference labs from those diagnosed with TB at the 13 selected Xpert laboratories between 1st July and 31st August 2018 in Karnataka, India.