Fig 1.
T1-weighted MRI with superimposed MRS 8 cm3 voxel.
(left–parasagittal; right–axial).
Fig 2.
Regions of interest of cortical networks as used in the CONN.
(Red–PCC/Pr; Yellow–MPFC; Green–left IPL; Magenta–right IPL).
Fig 3.
Example of LCModel output spectrum.
(Cr = creatine; PCr = phosphocreatine; GSH = glutathione; GABA = γ-amino butyric acid; NAA = N-acetylaspartic acid).
Table 1.
fMRI and MRS results.
Table 2.
Linear regressions.
Fig 4.
Glutamate/GABA concentration ratio in the PCC/precuneus vs age.
Fig 5.
Mean functional connectivity of the PCC/precuneus vs age (seed-based).
(Calculated as mean connectivity to the other ROIs expressed as Fisher transformed Z values; SB_FC = seed-based functional connectivity).
Fig 6.
Mean functional connectivity of the PCC/precuneus vs age (ICA-based).
(Calculated as mean connectivity to the other ROIs expressed as Fisher transformed Z values; ICA_FC = independent component analysis-based functional connectivity).