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Fig 1.

Flow chart of studies considered for inclusion.

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Table 1.

Nodule characteristics in the included studies.

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Table 2.

Results of pooled outcomes in the network meta-analysis and pairwise meta-analysis.

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Fig 2.

Evidence structure of eligible comparisons.

(A)Network diagrams of comparisons for the percentage mean change in benign thyroid nodule volume during 6-month follow-up after thermal/chemical ablation. (B) Network diagrams of comparisons for the percentage mean change in solid or predominantly solid benign thyroid nodule volume after thermal/chemical ablation. (C) Network diagrams of comparisons for the percentage mean change in cyst or predominantly cyst benign thyroid nodule volume after thermal/chemical ablation. RFA: Radiofrequency Ablation with single treatment session; RFA2: Radiofrequency Ablation with 2 treatment session; EA: ethanol ablation with single treatment session; EA3: ethanol ablation with 3 treatment session; LA: Laser Ablation with single treatment session; LA3: Laser Ablation with 3 treatment session. HIFU: High-Intensity Focused Ultrasound.

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Table 3.

Results of network meta-analysis for percentage mean volume change of benign thyroid nodules after percutaneous ablation therapies in 6- and 12-month follow-up and symptom score and cosmetic score change of benign thyroid nodules after percutaneous ablation therapies in 6 months.

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Table 4.

Results of network meta-analysis for percent mean volume change in the subgroup of solid or cyst benign thyroid nodules after percutaneous ablation therapies.

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Table 5.

SUCRA values and ranks of percentage mean volume changes, symptom score and cosmetic score.

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