Fig 1.
*Earliest outcome of interest, death, end of enrollment, or 52 weeks, whichever occurs first. BP–blood pressure; KP–Kaiser Permanente.
Fig 2.
Flowchart showing the application of exclusion criteria, text-processing tool, and IPTW to derive the final analytic cohorts.
IPTW–inverse probability of treatment weighting; KPCO–Kaiser Permanente Colorado.
Fig 3.
Achieved systolic (Panel A) and diastolic blood pressure (Panel B) among patients taking twice-daily versus once-daily lisinopril and losartan. Panel A: Proportion of patients achieving SBP <130 mmHg, 130–139 mmHg, 140–149 mmHg, and ≥150 mmHg. Panel B: Proportion of patients achieving DBP <80 mmHg, 80–89 mmHg, 90–99 mmHg, and ≥100 mmHg. SBP–systolic blood pressure; DBP–diastolic blood pressure.
Table 1.
Blood pressure outcomes among patients taking lisinopril daily or twice-daily for hypertension, by dosing cohort.
Table 2.
Adverse drug events among patients taking lisinopril once daily versus twice daily, by dosing cohort.
Table 3.
Adverse drug events among patients taking losartan once daily versus twice daily, by dosing cohort.