Fig 1.
Left and right cingulum templates used to extract the cingulum tract for each participant (A); Example of the cingulum bundle obtained for one subject displayed on the corresponding T1-weighted image (B). Along the fibers, color represents the RGB scale.
Fig 2.
Dot plot depicting distribution of cingulum free water content.
Table 1.
Characteristics of participants, 12-year verbal fluency decline and volumetric variables.
Table 2.
Cingulum diffusion measures before (conventional DTI) and after FW-correction and % of change between both measures for each group.
Fig 3.
Relationships between cingulum diffusion measures before (1) and after (2) FW-correction for (A, B) mean diffusivity and (C, D) radial diffusivity and verbal fluency decline. For the scatterplot the regression line is represented in blue and the 95% confidence interval in grey dotted line.
Table 3.
Correlations between cingulum diffusion measures and verbal fluency score (IST) before (conventional DTI) and after FW-correction.
Fig 4.
Relationships between cingulum free water content and verbal fluency at 15 (A) and 30 seconds (B). For the scatterplot the regression line is represented in blue and the 95% confidence interval in grey dotted line.