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Fig 1.

Study workflow.

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Table 1.

Patient characteristics.

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Table 1 Expand

Fig 2.

HCV genomic variants (Gene region).

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Fig 2 Expand

Fig 3.

HCV genomic variants (SVR vs. non-SVR).

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Fig 4.

Generalization performance of machine-learning algorithms.

SVM: Support vector machine, NN: Neural network, RF: Random forest, LR: Logistic regression, GBM: Gradient boost machine, KNN: K-nearest neighbor, FDA: Flexible discriminant analysis, DT: Decision tree, NB: naive Bayesian.

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Fig 4 Expand

Fig 5.

Training profile of machine-learning algorithms.

PPV: Positive predictive value, NPV: Negative predictive value, SVM: Support vector machine, NN: Neural network, KNN: K-nearest neighbor, LR: Logistic regression, RF: Random forest, FDA: Flexible discriminant analysis, GBM: Gradient boost machine, DT: Decision tree, NB: Naive Bayesian.

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Fig 6.

Correlation matrices of important variables.

SVM: Support vector machine, RF: Random forest, GBM: Gradient boost machine, NB: Naive Bayesian, KNN: K-nearest neighbor, LR: Logistic regression, NN: Neural network, FDA: Flexible discriminant analysis, DT: Decision tree.

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Fig 6 Expand

Table 2.

Performance evaluation of machine learning algorithms.

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Table 2 Expand