Table 1.
Covid-19 patient’s characteristics.
Fig 1.
Scatter plots representing the distribution obtained for control and SARS-CoV-2 case sera for three ELISA’s.
Red lines represent mean values with 95% confidence interval (CI). Dotted lines indicate the respective cut-off values to determine positive, borderline and negative test results. A) SARS-CoV-2 IgG antibody performance; B) SARS-CoV-2 IgM antibody performance; C) SARS-CoV-2 IgA antibody performance.
Table 2.
SARS-CoV-2 antibody performance using in house ELISA assay.
Fig 2.
Sensitivity of RBD ELISA based on time from first positive PCR.
Sensitivities of IgG (A), IgM (B) and IgA (C) in relation to the time passed since first positive PCR: 1 to 7 days (n = 11), 8 to 14 days (n = 28), and 15–42 days (n = 270). D. A BioVenn diagram resulting from comparison of positive results to IgG (orange), IgM (Green) and IgA (Blue) antibodies from 279 samples obtained from SARS-CoV-2 positive individuals which were identified by at least one of the immunoassays.
Fig 3.
Four to seven serum samples were obtained from each of 7 COVID-19 patients (marked patients 1–7) and IgM, IgG and IgA antibody levels were measured. Dotted line marks index value of 1.1 which separates between levels considered positive (≥1.1) and borderline or negative (<1.1).