Table 1.
Demographic and clinical characteristics of the patients in the present study.
Fig 1.
Numbers (A) and proportions (B) of patients with different kynurenine levels in HCC and Non-HCC group.
(A) The median serum kynurenine level of HCC group was significantly higher than that of non-HCC group (P <0.001). (B) The proportion of serum kynurenine level of ≧600 ng/mL in HCC group was significantly higher than in non-HCC group (P<0.001).
Table 2.
Clinical characteristics of the patients with HCC divided into three groups according to the kynurenine levels.
Table 3.
Variables associated with mortality of patients with HCC.
Fig 2.
Cumulative survival rates of HCC patients according to the kynurenine levels.
Cumulative survival rates of HCC patients according to kynurenine levels was analyzed using Kaplan-Meier’s method. Black solid, gray solid, and dotted lines indicate stratified kynurenine levels of <600, 600–899, and ≧900, respectively. Incidence rate differed significantly among the three groups by the log-rank test, increasing along with the kynurenine level.
Fig 3.
Cumulative survival rates of HCC according to the kynurenine level, stratified by Child-Pugh class.
Cumulative survival rates of HCC according to the kynurenine level were analyzed using Kaplan-Meier’s method. Black solid, gray solid, and dotted lines indicate stratified kynurenine levels of <600, 600–899, and ≧900 ng/mL, respectively. In Child-Pugh A, survival rates differed significantly among the three groups by the log-rank test, increasing along with the kynurenine level.
Fig 4.
Cumulative survival rates of HCC according to the kynurenine level, stratified by BCLC stage.
Cumulative survival rates of HCC according to the kynurenine level were analyzed using Kaplan-Meier’s method. Black solid, gray solid, and dotted lines indicate stratified kynurenine levels of <600, 600–899, and ≧900 ng/mL, respectively. In BCLC stage 0 and A, survival rates differed significantly among the three groups by the log-rank test, increasing along with the kynurenine level.