Table 1.
Patient characteristics and median PFS and OS by Notch1, Hes1, Ascl1 and DLL3 low vs. high expression.
Fig 1.
Expression of Notch1, Hes 1, Ascl1 and DLL3.
Representative immunohistochemical staining’s. Left panel: overview of the tumor biopsy (SCLC) with Hematoxylin and Eosin (HE) staining (top) and the expression of the different biomarkers (bottom), Middle panel: (1)–The localization of SCLC HE image (top), and the same area for high expression of the biomarker in IHC (bottom). Right panel: (2)–Normal lung tissue within the SCLC HE image (above), and the same are for the biomarker expression (below). (A) Notch1, (B) Hes 1, (C) Ascl1 and (D) DLL3. The arrows point at the representative SCLC cells in the HE images (top) as well as each biomarker (below).
Table 2.
Number of SCLC patients (n = 46) according to proportion of cancer cells positive for Notch1, Hes1, Ascl1 and DLL3 expression.
Fig 2.
Overall survival Kaplan-Meier curves for low vs high expression of biomarkers.
Notch 1 (A), Hes1 (B), Ascl1 (C), DLL3 (D).
Table 3.
Uni- and Multi-variate analysis of Notch1 expression adjusted for stage of disease and Lactate dehydrogenase.