Fig 1.
A: Location of 3D+5line cross OCT scans on retina. B: 26*26 grid centered on optic disc, the center area is not shown because the OCT thickness is always zero. C: cross-sectional OCT image and segmentation boundaries.
Fig 2.
Representation of the five layers measured by Triton optical coherence tomography.
Retina (from the inner limiting membrane–ILM- to the retinal pigment epithelium boundaries), Retinal nerve fiber layer (RNFL) (between the ILM to the GCL boundaries), Ganglion cell layer (GCL) + (between RNFL to the inner nuclear layer boundaries), GCL++ (between ILM to the inner nuclear layer boundaries), and choroid (from the Bruch membrane to the choroidal-scleral interface).
Fig 3.
Representation of mean and standard deviation for each layer measured by Triton optical coherence tomography, for the four age groups.
Group 1 (composed by 71 healthy subjects with age between 20 and 34 years); Group 2 (composed by 65 individuals with 35–49 years), Group 3 (with 230 healthy controls with 50–64 years) and Group 4 (composed by 97 healthy subjects with 65–79 years). On the left column, the mean and standard deviation is shown for each layer and age group. On the right column, the quartiles are plotted to show data dispersion and the presence of outliers.
Fig 4.
Finite element contour map of the evolution of the thickness of each layer measured by Triton optical coherence tomography for the four age groups (20–34 years, 35–49 years, 50–64 years, and 65–80 years).
On the left, the contour bar represents the equivalence between colour and thickness value (in μm) for each layer. Blue zones correspond to thicker areas and red zones correspond to thinner ones. The optic nerve is represented in grey colour. Different scales have been used to represent the thickness value for each layer. It can be seen a progressive thinning of all layers with age, especially from 50 years onwards.
Table 1.
Mean ± standard deviation of four quadrants and halves for age groups in the retinal nerve fiber layer, GCL+ and GCL++, and comparison of thickness between age groups.
Table 2.
Mean ± standard deviation of four quadrants and halves for age groups in the full layers, retina and choroid measurement, and comparison of thickness between age groups.