Fig 1.
CONSORT recruitment flowchart.
EN: Enteral nutrition; IC: Indirect calorimetry; ICU: Intensive care unit; RRT: Renal replacement therapy; TPN: Total parenteral nutrition.
Fig 2.
Schematic illustration of study protocol (not to scale).
EN: Enteral nutrition; IV: intravenous; Phe: Phenylalanine; T: Time; Tyr: Tyrosine.
Table 1.
General patient characteristics.
Table 2.
Anthropometric, nutritional and metabolic patient characteristics.
Table 3.
Individual patient nutritional and metabolic characteristics.
Fig 3.
Whole-body phenylalanine kinetics.
Black lines: individual patients; Red lines: mean. EN: Enteral nutrition. All p-values calculated with two-tailed Student’s T-test for paired samples.
Fig 4.
Plasma free amino acid concentrations.
Black lines with full circles: Individual patients. Black lines with hollow circles: Individual patients with continuous renal replacement therapy and amino acid supplementation. EN: Enteral nutrition.
Table 4.
Whole-body phenylalanine kinetics.
Table 5.
Plasma amino acid profiles of individual patients.
Fig 5.
Whole-body phenylalanine balance in relation to protein intake.
Black dots: individual patients with assigned numbers. Solid black line: Simple linear regression of data points. Dotted lines: 95% confidence interval of regression line.