Fig 1.
Positron emission tomography/computed tomography imaging using 11C-labeled Pittsburgh Compound-B ligand.
Positron emission tomography/computed tomography (PET/CT) imaging tracers provide a quantitative in vivo measure of the insoluble cortical beta amyloid (Aβ) load. 11C-Pittsburgh compound B (11C-PIB) shows a nanomolar affinity for the extracellular and intravascular fibrillar deposits of Aβ and a low affinity toward the amorphous amyloid deposits, soluble Aβ, and intracellular NFTs. Negative amyloid-PET (A) and positive amyloid-PET (B).
Fig 2.
Choroidal thickness measurements by EDI-OCT.
A representation of choroidal thickness (CT) measurements in the right eye that could be depicted in a patient with Alzheimer disease (A) and in the sex- and age-paired control eye (B) by optical coherence tomography. (1) CT measurements performed in the horizontal scan: subfoveal and at 500 μm, 1000 μm and 1500 μm from the fovea to nasal and temporal area. (2) CT assessment in the vertical scan: subfoveal and at 500 μm, 1000 μm and 1500 μm from the fovea to superior and inferior area.
Table 1.
Demographic and clinical participant’s characteristics of Alzheimer disease eyes and control eyes (126 eyes of 66 individuals).
Table 2.
Comparison of choroidal thickness analysis between Alzheimer PiB+ patients altogether and control eyes, mild cognitive impairment patients and control eyes and Alzheimer disease patients and controls.
Table 3.
Comparison of choroidal thickness analysis between mild cognitive impairment and dementia patients due to Alzheimer disease using a univariate generalized estimating equations model.
Fig 3.
AUC of CT I1500μm and CT I1000μm.
The area under the curve (AUC) of choroidal thickness (CT) at 1000 μm in inferior (I) (blue line) and at 1500 μm in inferior (green line) had the highest values under the curve and represented the most sensibility and specificity measurements.
Fig 4.
AUC of CT I1000μm in MCI patients, dementia patients and HCs.
Choroidal thickness (CT) at 1000 μm in inferior (I) sector in healthy controls (HCs), mild cognitive impairment (MCI) and dementia due Alzheimer’s disease (AD) eyes (error bars represent 95% confidence intervals), described on a bar chart.
Table 4.
Intraclass correlation coefficient used to determine interobserver reproducibility of manually quantified measurements and the confidence intervals associated.
Table 5.
Correlation of mini-mental state examination with each measurement of choroidal thickness.