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Fig 1.

Flowchart of study.

The figure shows selection of subjects and reason for exclusion. Abbreviation: hs-CRP: High sensitivity C-reactive Protein.

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Table 1.

Baseline characteristics.

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Table 1 Expand

Fig 2.

Boxplot representing change of hs-CRP levels after 30 days of colchicine exposure.

The figure shows the change in median hs-CRP levels after 30 days of colchicine exposure. Abbreviation: hs-CRP: High sensitivity C-reactive Protein.

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Fig 3.

a. Median change in hs-CRP. The figure shows the median change in hs-CRP and IL-6 levels after 30 days of colchicine exposure. Horizontal lines represent 95% confidence intervals. Abbreviations: hs-CRP, High sensitivity C-reactive Protein; IL-6, interleukin-6. b. Absolute change in hs-CRP & IL-6. The figure shows a waterfall plot of change in hs-CRP from baseline to 30 days after colchicine exposure. Vertical bars in the plot represent individual patients. Abbreviations: hs-CRP, high sensitivity C-Reactive Protein; IL-6, interleukin-6.

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Table 2.

Inflammatory markers and lipids.

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Table 2 Expand

Fig 4.

Subgroup changes in hs-CRP.

The figure shows the median change in hs-CRP after 30 days of colchicine exposure in four subgroups. An asterisk depicts p-values < 0.05 for the paired and non-paired comparisons. In all subgroups hs-CRP decreased significantly. There was no significant interaction of the subgroups and change in hs-CRP. Abbreviations: hs-CRP, high sensitivity C-Reactive Protein; NS, not significant.

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Table 3.

Differences in inflammatory markers between subgroups.

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Table 3 Expand

Table 4.

Haematology and renal function.

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Table 4 Expand