Fig 1.
Proposed strategy for SARS-CoV-2 neutralization by ACE2-Fc immunoadhesin.
ACE2-Fc binds to the spike (S) protein on the virus and blocks binding to the human cellular receptor ACE2, preventing cellular entrance of SARS-CoV-2.
Fig 2.
Infographic of the ACE2-Fc variant 1 homodimer bound to two SpFr.
Fig 3.
Glycans used in the simulated systems.
All structures were built using GlycanBuilder [37].
Table 1.
Description of simulated systems.
Fig 4.
Initial (left) and 75 ns simulated (right) configurations of all systems.
Fig 5.
Backbone RMSD profiles of ACE2 (top) and Fc (bottom) ordered domains referenced to initial and final simulation configurations. ACE2: residues 4–707. Fc: residues 745–950. (see S1 File).