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Fig 1.

CONSORT flow diagram.

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Table 1.

Comparison of demographic and clinical characteristics, by treatment group.

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Fig 2.

Time from randomization to treatment initiation (T0), by treatment group.

Abbreviations: IN, intranasal; IV, intravenous.

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Fig 2 Expand

Fig 3.

Median pain scores across time, by treatment group.

Abbreviations: IN, intranasal; IV, intravenous; NRS, numerical rating scale.

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Fig 3 Expand

Table 2.

Pain ratings 60 minutes after treatment initiation (T0), by treatment group.

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Table 2 Expand

Fig 4.

Change in pain scores from randomization to 60 minutes after treatment initiation (T0), by treatment group.

Abbreviations: IN, intranasal; IV, intravenous; NRS, numerical rating scale. Individual points are jittered for readability.

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Fig 4 Expand

Table 3.

Decrease in pain ratings from treatment initiation (T0) to one hour later, using two methods to estimate pain ratings at T0.

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Table 3 Expand