Table 1.
Efficiency of the decontamination solutions on the 23 tested antineoplastic drugs on stainless steel surfaces after standard single motion.
Solution 1 (S1): 70% isopropanol; Solution 2 (S2): ethanol (91.6 mg/g) hydrogen peroxide (50.0 mg/g); Solution 3 (S3): 10−2 M sodium dodecyl sulfate:isopropanol 80:20; Solution 4 (S4): 0.5% sodium hypochlorite aqueous solution. 5FU: 5-fluorouracil; Cyta: cytarabine; Fluda: fludarabine; Ganci: ganciclovir; Gem: gemcitabine; Mtx: methotrexate; Peme: pemetrexed; Ralti: raltitrexed; Busu: busulfan; Cyc: cyclophosphamide; Ifos: ifosphamide; Dacar: dacarbazine; Dauno: daunorubicin; Doxo: doxorubicin; Ida: idarubicin; Epi: epirubicin; EtopoP: etoposide phosphate; Eto: etoposide; Dtx: docetaxel; Pcx: paclitaxel; Irino: irinotecan; Topo: topotecan; Vin: vincristine.
Fig 1.
Comparison of decontamination efficiency per contaminant of four decontamination or deactivation solutions after standard single motion.
Values represented are median Effq for each drug (n = 6). 5FU: 5-fluorouracil; Cyta: cytarabine; Fluda: fludarabine; Ganci: ganciclovir; Gem: gemcitabine; Mtx: methotrexate; Peme: pemetrexed; Ralti: raltitrexed; Busu: busulfan; Cyc: cyclophosphamide; Ifos: ifosphamide; Dacar: dacarbazine; Dauno: daunorubicin; Doxo: doxorubicin; Ida: idarubicin; Epi: epirubicin; EtopoP: etoposide phosphate; Eto: etoposide; Dtx: docetaxel; Pcx: paclitaxel; Irino: irinotecan; Topo: topotecan; Vin: vincristine. Blue line/circles: 70% isopropanol; red line/triangles: admixture of ethanol-hydrogen peroxide (91.6–50.0 mg/g); green line/diamonds: admixture of 10−2 M sodium dodecyl sulfate/isopropanol (80/20) and yellow line/squares: sodium hypochlorite. * Significant difference for solution 4 over other solutions; ** Significant difference between solutions 4 and 2; $ significant difference between solutions 4 and 1 and between $ $ solutions 4 and 3. + significant difference for both solutions 3 and 4 compared to others.
Table 2.
Efficiency of the decontamination solutions on the 23 tested antineoplastic drugs on stainless steel surfaces after vigorous decontamination.
Solution 1 (S1): 70% isopropanol; Solution 2 (S2): ethanol (91.6 mg/g) hydrogen peroxide (50.0 mg/g); Solution 3 (S3): 10−2 M sodium dodecyl sulfate:isopropanol 80:20; Solution 4 (S4): 0.5% sodium hypochlorite aqueous solution. 5FU: 5-fluorouracil; Cyta: cytarabine; Fluda: fludarabine; Ganci: ganciclovir; Gem: gemcitabine; Mtx: methotrexate; Peme: pemetrexed; Ralti: raltitrexed; Busu: busulfan; Cyc: cyclophosphamide; Ifos: ifosphamide; Dacar: dacarbazine; Dauno: daunorubicin; Doxo: doxorubicin; Ida: idarubicin; Epi: epirubicin; EtopoP: etoposide phosphate; Eto: etoposide; Dtx: docetaxel; Pcx: paclitaxel; Irino: irinotecan; Topo: topotecan; Vin: vincristine.
Fig 2.
Comparison of the decontamination efficiency per contaminant of four decontamination or deactivation solutions after vigorous decontamination.
Values represented are median Effq for each drug (n = 6). 5FU: 5-fluorouracil; Cyta: cytarabine; Fluda: fludarabine; Ganci: ganciclovir; Gem: gemcitabine; Mtx: methotrexate; Peme: pemetrexed; Ralti: raltitrexed; Busu: busulfan; Cyc: cyclophosphamide; Ifos: ifosphamide; Dacar: dacarbazine; Dauno: daunorubicin; Doxo: doxorubicin; Ida: idarubicin; Epi: epirubicin; EtopoP: etoposide phosphate; Eto: etoposide; Dtx: docetaxel; Pcx: paclitaxel; Irino: irinotecan; Topo: topotecan; Vin: vincristine. Blue line/circles: 70% isopropanol; red line/triangles: admixture of ethanol-hydrogen peroxide (91.6–50.0 mg/g); green line/diamonds: admixture of 10−2 M sodium dodecyl sulfate/isopropanol (80/20) and yellow line/squares: sodium hypochlorite. + significant difference for both solutions 3 and 4 compared to others.; @ significant differences between the 4 solutions; * significant difference of solution 4 over other solutions.
Fig 3.
Comparison of the overall efficiency of four decontamination or deactivation solutions according to their application modalities.
White boxes represent standard decontamination and striped boxes represent vigorous decontamination. The solutions compared are 70% isopropanol (IPA), an admixture of ethanol-hydrogen peroxide (91.6–50.0 mg/g), an admixture of 10−2 M sodium dodecyl sulfate/isopropanol (80/20) and sodium hypochlorite (NaOCl). Significant differences are observed for single standard motion between NaOCl and the other solutions and for vigorous application for both NaOCl and SDS/IPA compared to the two other solutions.