Fig 1.
Transmission electron micrographs of the four S. agalactiae phages (LF1 –LF4).
Scale bar of 50 nm included in each micrograph.
Table 1.
S. agalactiae phages LF1, LF2, LF3 and LF4 virion measurements*.
Fig 2.
Representative examples of the spot test outcomes including plaques, clear, turbid and negative.
Fig 3.
The relationship between S. agalactiae host serotype and LF1 (panel A, n = 125/256), LF2 (panel B, n = 91/256), LF3 (panel C, n = 75/256) and LF4 (panel D, n = 151/256) phage activity presented as the number of isolates that were sensitive (plaques, black; clearing, light grey; and turbidity, dark grey) and their serotype.
Table 2.
The host range activity of four S. agalactiae phages against clinical carriage (antenatal) and disease (neonatal) S. agalactiae isolates (n = 256).
The activity is divided into plaque formation, clear lysis zones, turbid zones and no activity.
Fig 4.
The organisation of genes in the genomes of four S. agalactiae phages with modules highlighted.
Fig 5.
Comparative alignment of all S. agalactiae phages demonstrating the percentage nucleotide similarity of the different genomes (colour scale percentage similarity).
Fig 6.
The neighbour-joining phylogenetic tree analysis of LF1 –LF4 phages (purple) and 263 complete Streptococcus phage genomes and their respective viral families.