Fig 1.
a Parallel alignment of stroma fibers, arrows pointing at elongated parallel oriented extracellular matrix fibers; b Random orientation of stroma fibers, arrows pointing at extracellular matrix fibers aligned at an angle of more than 45°. 20x magnification.
Fig 2.
a High stromal density, arrows pointing at dense bunches of extracellular matrix; b Low stromal density, arrows pointing at thin elongated extracellular matrix fibers showing gaps between the single fibers. 20x magnification.
Fig 3.
a High fibroblast density, arrows pointing at densely arranged fibroblasts; b Low fibroblast density, arrows pointing at rarely scattered fibroblasts throughout the stromal areas. 20x magnification.
Fig 4.
a Arrow pointing at round-shaped fibroblasts; b Arrow pointing at spindle-like shaped fibroblasts. 20x magnification.
Fig 5.
a High microvessel density, arrow pointing at densely arranged microvessels; b Low microvessel density, arrow pointing at rarely scattered microvessels. 10x magnification.
Fig 6.
a Immunohistochemistry staining for CD4; b Immunohistochemistry staining for CD3; Immunohistochemistry staining for CD163. 20x magnification.
Table 1.
Baseline parameters, histopathology and stroma morphology.
Table 2.
Stroma morphology and histopathology.
Fig 7.
Overall survival random orientation of stroma fibers and low microvessel density.
Table 3.
Survival analysis.